Particle Spread
playableparticle_spread · biology · simulator.predict
Concept: Diffusion
Player does: Predict how particles spread from the crowded chamber
Breaks: Particles move toward empty space on purpose
Particles move randomly and simply spread out net from high to low concentration; they have no destination in mind.
Membrane Balance
playablemembrane_balance · biology · simulator.predict
Concept: Osmosis
Player does: Predict which way water crosses and whether the cell swells or shrinks
Breaks: Salt crosses the membrane instead of water
In osmosis, water crosses the semipermeable membrane toward the higher solute concentration; the solute itself often cannot cross.
ATP Gate
playableatp_gate · biology · simulator.intervene
Concept: Active transport
Player does: Spend ATP to pump ions against the gradient before the budget runs out
Breaks: Transport always goes down the gradient
Active transport uses ATP to move substances against their concentration gradient, unlike passive diffusion.
Membrane Router
playablemembrane_router · biology · sorter.bins
Concept: Membrane selectivity
Player does: Route molecules to simple diffusion, channel, or pump
Breaks: Anything small passes freely
The membrane is selectively permeable, so a molecule's charge and polarity, not just its size, decide its crossing route.
Shape Docking
playableshape_docking · biology · linker.pairs
Concept: Enzyme specificity
Player does: Dock each substrate into its matching active site
Breaks: Enzymes are used up in reactions
An enzyme's active site releases the product and is reused, so the enzyme itself is not consumed.
Dock Blocker
playabledock_blocker · biology · simulator.predict
Concept: Competitive inhibition
Player does: Decoys occupy sites; predict how much more substrate restores the rate
Breaks: Inhibitors destroy enzymes
A competitive inhibitor blocks the active site reversibly; adding more substrate can outcompete it and restore the reaction rate.
Genome Repair
playablegenome_repair · biology · transformer.encode
Concept: DNA base pairing
Player does: Rebuild the damaged strand by complementary pairing
Breaks: A pairs with G
DNA base pairing is fixed: A pairs with T, and G pairs with C.
RNA Assembly
playablerna_assembly · biology · transformer.encode
Concept: Transcription
Player does: Read the template strand and assemble the mRNA (U for T)
Breaks: mRNA is an exact copy of the template strand
mRNA is complementary to the DNA template strand, not an identical copy, and it swaps thymine for uracil.
★ Protein Factory
playableprotein_factory · biology · transformer.encode
Concept: Translation
Player does: Route codons to amino acids with the codon table to build the chain
Breaks: Each nucleotide codes for one amino acid
A group of three nucleotides, a codon, specifies one amino acid, not a single nucleotide.
Chromosome Logistics
playablechromosome_logistics · biology · sequencer.linear
Concept: Mitosis
Player does: Duplicate and separate chromosome sets in stage order
Breaks: Chromosomes duplicate during prophase
Chromosomes duplicate during interphase, before mitosis's stages of prophase, metaphase, anaphase, and telophase begin.
Meiosis Shuffle
playablemeiosis_shuffle · biology · simulator.sample
Concept: Meiosis & variation
Player does: Shuffle homolog pairs; predict how many gamete types appear
Breaks: Meiosis makes identical cells
Meiosis shuffles homologous chromosomes to produce genetically varied gametes, not identical cells.
Punnett Forge
playablepunnett_forge · biology · builder.genetics
Concept: Mendelian genetics
Player does: Fill the Punnett square to breed a familiar with the needed trait
Breaks: Dominant traits are always the most common
A trait's frequency in a population depends on allele frequency, not simply on whether the allele is dominant.
Survival Sim
playablesurvival_sim · biology · simulator.predict
Concept: Natural selection
Player does: Change the environment; predict which trait spreads
Breaks: Individuals evolve because they need to
Natural selection acts on existing variation across a population over generations; individuals themselves do not evolve by need.
Drift Sim
playabledrift_sim · biology · simulator.sample
Concept: Genetic drift
Player does: Run tiny populations and watch alleles vanish by chance
Breaks: Evolution always improves fitness
Genetic drift changes allele frequencies by random chance, especially in small populations, regardless of fitness.
Ecosystem Network
playableecosystem_network · biology · linker.network
Concept: Food webs
Player does: Remove a species; trace the cascade through the web
Breaks: Removing a predator helps every other species
Removing a predator can trigger a cascade that harms some species, such as prey overpopulating and depleting their own food.
Energy Pyramid
playableenergy_pyramid · biology · tuner.formula
Concept: Energy flow (≈10% rule)
Player does: Size each trophic level from the energy passed up
Breaks: Energy is recycled like matter
Energy flows one way through an ecosystem and is mostly lost as heat at each level, unlike matter, which cycles.
★ Feedback Controller
playablefeedback_controller · biology · simulator.intervene
Concept: Homeostasis
Player does: Release insulin or glucagon to keep glucose in the safe band
Breaks: Hormones switch on and stay on
Hormonal control in homeostasis is a continuous feedback loop, releasing and easing off as the level shifts, not an on/off switch.
Threshold Pulse
playablethreshold_pulse · biology · simulator.intervene
Concept: Action potentials
Player does: Stack inputs until threshold fires an all-or-none spike
Breaks: Stronger stimuli make bigger action potentials
An action potential is all-or-none once it fires; a stronger stimulus raises firing frequency, not the spike's size.
Organelle City
playableorganelle_city · biology · linker.pairs
Concept: Organelle functions
Player does: Assign each city service to its organelle
Breaks: Plant cells don't have mitochondria
Plant cells have mitochondria for cellular respiration in addition to chloroplasts for photosynthesis.
Taxonomy Tower
playabletaxonomy_tower · biology · sorter.hierarchy
Concept: Classification hierarchy
Player does: Nest kingdom through species into a climbable tower
Breaks: Species that look alike are closest relatives
Taxonomic closeness is based on shared ancestry and genetics, and can differ from superficial resemblance.
Levels Tower
playablelevels_tower · biology · sequencer.linear
Concept: Levels of organization
Player does: Climb cell → tissue → organ → system → organism
Breaks: Organs are built directly from cells
Cells form tissues, tissues form organs, so organs are built from tissues, not directly from cells.
Photosynthesis Recipe
playablephotosynthesis_recipe · biology · transformer.composition
Concept: Photosynthesis
Player does: Route light, water, CO₂ through the stations to make glucose
Breaks: Plants get their mass from the soil
Most of a plant's mass comes from carbon dioxide fixed by photosynthesis, not from the soil.
Respiration Forge
playablerespiration_forge · biology · transformer.composition
Concept: Cellular respiration
Player does: Run glucose through glycolysis, Krebs, and the ETC to charge ATP
Breaks: Plants don't do cellular respiration
Plants perform cellular respiration to make ATP just as animals do, in addition to photosynthesis.
Krebs Wheel
playablekrebs_wheel · biology · sequencer.cycle
Concept: Krebs cycle
Player does: Rotate the wheel so each intermediate feeds the next
Breaks: Glucose enters the Krebs cycle directly
Glucose is broken down to pyruvate and then acetyl-CoA before entering the Krebs cycle, not directly.
Heart Run
playableheart_run · biology · sequencer.linear
Concept: Blood flow
Player does: Sprint through the chambers in blood-flow order; valves are one-way gates
Breaks: All arteries carry oxygen-rich blood
The pulmonary artery carries deoxygenated blood to the lungs, so arteries are not defined by carrying oxygen-rich blood.
Boss Anatomy
playableboss_anatomy · biology · linker.pairs
Concept: Parts & functions
Player does: Strike the weak point whose function the announcer names
Breaks: The right side of the heart pumps to the body
The right side of the heart pumps to the lungs, while the left side pumps oxygenated blood to the body.
Immune Defense
playableimmune_defense · biology · sorter.type_match
Concept: Innate vs adaptive immunity
Player does: Deploy the right defender against each invader
Breaks: Antibiotics kill viruses
Antibiotics target bacterial processes and have no effect on viruses.
Vaccine Memory
playablevaccine_memory · biology · simulator.predict
Concept: Immunological memory
Player does: Predict how fast the second infection is cleared
Breaks: Vaccines give you the disease
A vaccine trains memory cells to recognize a pathogen without causing the actual disease.